Demyelination and neurological signs in experimental allergic encephalomyelitis

Demyelination and neurological signs in experimental allergic encephalomyelitis.

Because of the reported absence of demyelination in some animals with neurological signs of experimental allergic encephalomyelitis (EAE), it has been suggested that these signs are not due to demyelination. The present study demonstrates that there is ample demyelination in the central nervous system (CNS) and peripheral nervous system (PNS) to account for the neurological signs in rats with m...

nerve growth factor prevents demyelination, cell death and progression of the disease in experimental allergic encephalomyelitis

experimental allergic encephalomyelitis (eae), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. in this study, we have therefore used this model to study functions of nerve growth factor (ngf) in eae. ngf with considerable effects on neuron survival, proliferation and differentiati...

Demyelination and Nerve Conduction Abnormalities in Acute and Chronic Experimental Allergic Encephalomyelitis in the Lewis Rat

We have been using histological and electrophysiological techniques to compare the pathology and pathophysiology in different forms of experimental allergic encephalomyelitis (EAE) in the Lewis rat. In acute EAE induced by sensitization to myelin basic protein (MBP) or by the passive transfer of MBPspecific lymphocytes, there is inflammation and demyelination in the ventral and dorsal spinal ro...

A Novel MRI Texture Analysis of Demyelination and Inflammation in Relapsing-Remitting Experimental Allergic Encephalomyelitis

We have developed a novel multiscale localized image texture analysis technique, based upon the polar Stockwell Transform (PST). In this paper we characterized image texture in vivo using the PST in histologically verified lesion areas in T2-weighted MRI of an animal model of multiple sclerosis. Both high and low frequency signals, representing inflammation and demyelination, were significantly...

Experimental Allergic Encephalomyelitis Inflammation and Demyelination in Stat4 Isoforms Differentially Regulate